Table 5

In vivo effects of KMD-3213 and reference compounds after i.d. administration in the anesthetized rat model

CompoundIncrease in IUP ID50MBP ED15Uroselectivity (ED15/ID50)Relative Selectivity to Prazosin
μg/kg i.d.

Data represent the active doses inhibiting by 50% the increase in IUP response to PHE and the active doses in lowering MBP by 15% of the initial value. Uroselectivity indicates the ratio between doses (ED15 value of MBP/ID50 value of increase in IUP), and relative selectivity indicates the relative uroselectivity when the uroselectivity for prazosin is taken as 1.