In vivo effects of KMD-3213 and reference compounds after i.d. administration in the anesthetized rat model
| Compound | Increase in IUP ID50 | MBP ED15 | Uroselectivity (ED15/ID50) | Relative Selectivity to Prazosin |
|---|---|---|---|---|
| μg/kg i.d. | ||||
| KMD-3213 | 54 | 870 | 16.1 | 32.2 |
| Tamsulosin | 19 | 61 | 3.2 | 6.4 |
| Prazosin | 48 | 24 | 0.5 | 1 |
Data represent the active doses inhibiting by 50% the increase in IUP response to PHE and the active doses in lowering MBP by 15% of the initial value. Uroselectivity indicates the ratio between doses (ED15 value of MBP/ID50 value of increase in IUP), and relative selectivity indicates the relative uroselectivity when the uroselectivity for prazosin is taken as 1.