Table 4

Neuroprotective effects of early treatment with compound 2711 and its (R)-isomer (2726) and (S)-isomer (2727) after transient focal ischemia in rats

Treatment	(Dose)	n	Motor Behavior Score		Brain Damage
Treatment	(Dose)	n	24 h	48 h	72 h	96 h	A	B	C
							mm²
Saline		12	1.3 ± 0.4	1.3 ± 0.3	1.4 ± 0.3	1.3 ± 0.3	3.3 ± 0.1	10.4 ± 2.0	5.2 ± 0.5
2711	1 mg/kg	6	1.1 ± 0.2	1.0 ± 0.2	0.3 ± 0.2^4-150	0.2 ± 0.1^4-150	3.8 ± 0.7	3.3 ± 0.8^4-150	2.0 ± 0.3^4-150
	5 mg/kg	6	0.7 ± 0.1^4-150	0.7 ± 0.1^4-150	0.7 ± 0.1^4-150	0.2 ± 0.1^4-150	1.9 ± 0.6^4-150	3.1 ± 1.2^4-150	3.8 ± 0.7^4-150
	10 mg/kg	12	1.0 ± 0.1	1.0 ± 0.2	0.4 ± 0.1^4-150	0.2 ± 0.1^4-150	0.9 ± 0.4^4-150	0.6 ± 0.1^4-150	1.2 ± 0.3^4-150
2726	1 mg/kg	6	1.8 ± 0.2	1.3 ± 0.2	0.8 ± 0.1^4-150	0.3 ± 0.1^4-150	4.6 ± 0.5	4.1 ± 0.9^4-150	4.3 ± 0.5
	5 mg/kg	6	1.8 ± 0.2	1.3 ± 0.2	1.3 ± 0.2	1.1 ± 0.2	4.7 ± 1.2	14.2 ± 1.6	4.9 ± 1.1
2727	1 mg/kg	6	1.2 ± 0.1	1.0 ± 0.1	0.3 ± 0.1^4-150	0.2 ± 0.1^4-150	4.1 ± 1.7	6.4 ± 2.0^4-150	3.5 ± 1.0^4-150
	5 mg/kg	6	1.5 ± 0.1	1.7 ± 0.1	1.7 ± 0.1	0.9 ± 0.1^4-150	1.9 ± 0.6^4-150	3.1 ± 1.2^4-150	3.8 ± 0.7^4-150