Table 3

Neuroprotective effects of early treatment with PAs and PA derivatives in the hippocampus 14 days after global ischemia in gerbils

CompoundDoseProtection3-a
n mg/kg %
Putrescine1010.041  ± 3.03-150
Spermidine1010.042  ± 3.13-150
Spermine1010.060  ± 5.33-150
(R)-1-Aminoindan40.125  ± 2.13-150
41.025  ± 1.83-150
410.025  ± 2.33-150
270941.012  ± 1.0
810.031  ± 2.73-150
271041.025  ± 2.03-150
810.037  ± 3.13-150
271141.050  ± 3.73-150
1710.080  ± 4.13-150,3-160
271541.075  ± 7.73-150
710.050  ± 4.53-150
271641.050  ± 4.13-150
710.00
27201210.058  ± 5.13-150
272181.012  ± 1.0
610.067  ± 5.73-150
272241.050  ± 4.83-150
410.025  ± 1.93-150
272441.012  ± 1.1
1310.056  ± 4.63-150
272541.00
410.025  ± 2.23-150
272841.020  ± 1.53-150
1010.060  ± 5.33-150
2726410.050  ± 4.73-150
2727710.049  ± 4.23-150

  • ↵3-150  p < .01 compared with saline-treated animals.

  • ↵3-160  p < .01 compared with spermine-treated animals.

  • ↵3-a The percent protection values are the mean ± S.E. values of remaining neurons after ischemia expressed as a percentage of neuron numbers in unoperated control animals.