Pharmacokinetic parameters of nifedipine (0.1 mg · kg−1i.v.) in NL, HL, HLA, and AT groups
| NL | AT | HLA | HL | Statistical Comparisons1-a | |
|---|---|---|---|---|---|
| AUCT(0–∞)(μg · ml−1 min) | 17.2 ± 2.6 | 17.9 ± 6.6 | 21.7 ± 5.8 | 28.5 ± 3.3 | AT NL HLAHL |
| AUCU(0–∞) (μg · ml−1 min) | 0.6 ± 0.09 | n.d. | n.d. | 0.7 ± 0.08 | NL HL |
| AUCT(0–30 min) (μg · ml−1 min) | 8.3 ± 0.8 | n.d. | n.d. | 9.0 ± 1.2 | NL HL |
| AUCU(0–30 min) (μg · ml−1 min) | 0.3 ± 0.03 | n.d. | n.d. | 0.2 ± 0.02 | NL HL |
| CIsys (ml · min−1kg−1) | 5.92 ± 0.93 | 6.14 ± 1.73 | 4.95 ± 1.54 | 3.55 ± 0.42 | AT NL HLAHL |
| T 1/2 (min) | 34 ± 11 | 30 ± 12 | 46 ± 15 | 63 ± 14 | AT NL HLA HL |
| Vdss (ml · kg−1) | 268 ± 44 | 227 ± 22 | 278 ± 35 | 309 ± 34 | AT NL HLA HL |
↵1-a n.d., not determined. Groups connected with underline are not significantly different. Data are presented as mean ± S.D.