CYP2E1 synthesis rate and degradation half-life in individual subjects estimated from return of CLZ clearance following a single DSF dose
| Subject | CYP2E1 Degradation T1/2 | CYP2E1 Synthesis |
|---|---|---|
| h | nmol/h | |
| AA | 32.5 | 15 |
| BB | 46.1 | 11 |
| DD | 24.9 | 20 |
| EE | 58.3 | 9 |
| FF | 59.2 | 8 |
| GG | 32.3 | 15 |
| HH | 34.5 | 14 |
| II | 80.0 | 6 |
| JJ | 63.4 | 8 |
| KK | 73.5 | 7 |
| Mean | 50.5 | 11 |
| S.D. | 19.1 | 5 |
Based on analysis of the data in Fig. 2 as described inMaterials and Methods.