Table 1

CLZ pharmacokinetic parameters before and after single-dose DSF

Study PeriodCLZ ClearanceFraction Metabolized to 6-OH CLZ6-OH CLZ Fractional Metabolic ClearanceCLZ T1/2
liter h−1 % liter h−1 liter h−1
Baseline29.9  ± 20.10.56  ± 0.1816.7  ± 10.71.6  ± 0.7
Day 12.92  ± 1.33* 0.27  ± 0.15* 0.83  ± 0.65* 13.2  ± 6.0*
Day 316.1  ± 10.8* 0.52  ± 0.178.4  ± 5.5* 2.6  ± 1.4
Day 625.6  ± 12.000.61  ± 0.1515.7  ± 7.61.7  ± 0.6
Day 830.3  ± 14.60.58  ± 0.1918.5  ± 11.31.4  ± 0.4
Day 1026.9  ± 9.70.55  ± 0.1614.6  ± 6.21.8  ± 0.7
Day 1328.5  ± 12.000.55  ± 0.2316.2  ± 12.21.6  ± 0.4

CLZ (500 mg p.o.) was administered before, and 1, 3, 6, 8, 10, and 13 days after oral DSF (500 p.o.).

  • p < .05 versus baseline.