|
μmol/h/kg
|
SDRs | 0.067 | 0.0903 ± 0.009 | 0.118 ± 0.009 | 0.123 ± 0.013 | 0.137 ± 0.011 | 0.139 ± 0.013 | 0.137 ± 0.018 |
| 0.334 | 0.462 ± 0.037 | 0.582 ± 0.042 | 0.553 ± 0.019 | 0.613 ± 0.018 | 0.600 ± 0.015 | 0.684 ± 0.016 |
Plasma concentration (μM) | 1.67 | 2.94 ± 0.37 | 3.39 ± 0.39 | 3.87 ± 0.39 | 4.03 ± 0.48 | 4.44 ± 0.55 | 3.67 ± 1.00 |
| 8.36 | 13.3 ± 1.3 | 16.6 ± 1.7 | 17.4 ± 1.6 | 19.7 ± 2.2 | 21.2 ± 2.4 | 20.8 ± 2.8 |
| 33.4 | 96.7 ± 13.5 | 120 ± 17 | 123 ± 21 | 131 ± 15 | 137 ± 14 | 135 ± 15 |
| 0.067 | 0.147 ± 0.044 | 0.413 ± 0.097 | 3.10 ± 0.88 | 14.1 ± 3.3 | 26.5 ± 5.8 | 35.0 ± 5.0 |
| 0.334 | 52.3 ± 10.5 | 161 ± 14 | 212 ± 11 | 223 ± 18 | 247 ± 25 | 291 ± 38 |
Biliary excretion rate | 1.67 | 324 ± 46 | 836 ± 73 | 1120 ± 20 | 1080 ± 60 | 1060 ± 40 | 1170 ± 50 |
(pmol/h/kg) | 8.36 | 1,880 ± 150 | 4,150 ± 310 | 4,750 ± 400 | 4,790 ± 660 | 5,000 ± 500 | 5,680 ± 680 |
| 33.4 | 10,100 ± 1,900 | 21,700 ± 4,100 | 27,400 ± 2,200 | 35,900 ± 4,000 | 35,800 ± 1,200 | 31,600 ± 1,500 |
| 0.067 | | 7.70 ± 1.50 | | 16.5 ± 1.7 | | 18.3 ± 2.0 |
Urinary excretion rate | 0.334 | | 22.0 ± 5.9 | | 95.9 ± 15.5 | | 110 ± 13 |
(pmol/h/kg) | 1.67 | | 307 ± 100 | | 341 ± 101 | | 382 ± 70 |
| 8.36 | | 945 ± 104 | | 1,180 ± 110 | | 1,600 ± 150 |
| 33.4 | | 4,370 ± 490 | | 7,070 ± 650 | | 6,480 ± 840 |
EHBRs |
Plasma concentration (μM) | 0.067 | 0.105 ± 0.009 | 0.149 ± 0.015 | 0.162 ± 0.015 | 0.174 ± 0.022 | 0.186 ± 0.019 | 0.198 ± 0.029 |
| 1.67 | 3.71 ± 0.15 | 5.60 ± 0.55 | 5.99 ± 0.72 | 7.35 ± 0.70 | 7.80 ± 0.90 | 7.90 ± 0.71 |
| 33.4 | 73.6 ± 5.4 | 113 ± 9 | 137 ± 16 | 159 ± 21 | 180 ± 35 | 200 ± 42 |
Biliary excretion rate | 0.067 | 0.0302 ± 0.072 | 0.0837 ± 0.0166 | 0.0974 ± 0.0194 | 0.113 ± 0.009 | 0.170 ± 0.017 | 0.340 ± 0.127 |
(nmol/h/kg) | 1.67 | 1.65 ± 0.78 | 20.0 ± 7.0 | 39.7 ± 10.1 | 51.0 ± 13.0 | 58.4 ± 13.6 | 59.0 ± 13.5 |
| 33.4 | 98.8 ± 35.1 | 518 ± 104 | 736 ± 135 | 1,150 ± 292 | 1,060 ± 223 | 1,280 ± 340 |
Urinary excretion rate | 0.067 | | 9.45 ± 2.33 | | 15.0 ± 3.7 | | 26.5 ± 3.0 |
(nmol/h/kg) | 1.67 | | 277 ± 72 | | 611 ± 186 | | 767 ± 185 |
| 33.4 | | 6,070 ± 950 | | 12,100 ± 2,400 | | 13,800 ± 2,700 |