Effect of H3 receptor agonists and antagonists on rat brain MC granule ultrastructure
| Activated Granules | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No. | Condition | Activated MC | Total Granules | Intact Granules | Empty granules | Partially empty granules | Granules with “fibrillar material” | Total of Activated Granules | Activated Granules | p |
| % total | n | n | n | n | % total | |||||
| 1 | Control (unstimulated) (n = 15) | 9 | 242 | 209 | 7 | 25 | 1 | 33 | 14 | N.A. |
| 2 | C48/801-a (n = 8) | 42 | 133 | 61 | 7 | 61 | 4 | 72 | 54 | <.05 vs 1 |
| 3 | Nα-mH + C48/80 (n = 10) | 11 | 185 | 150 | 8 | 27 | 0 | 35 | 19 | <.05 vs 2 |
| 4 | Nα-mH + Th + C48/80 (n = 9) | 35 | 130 | 57 | 8 | 25 | 0 | 33 | 37 | <.05 vs 2 |
| 5 | Th + C48/80 (n = 11) | 73 | 191 | 62 | 25 | 97 | 7 | 129 | 68 | <.05 vs 2 |
n = number of cells studied in four separate experiments.
↵1-a C48/80 (100 μg/ml).
N.A., not applicable.