Table 2

DA uptake as a function of DA concentration at various cationic conditions

[Na+]Substituted CationsnHiCoefficientK[DA]Vapp
mM μM pmol/s/mg
15581.04  ± 0.072.66  ± 0.1837.2  ± 1.5
 55Li+ 70.96  ± 0.074.95  ± 0.462-a 43.4  ± 1.7
Choline51.01  ± 0.026.24  ± 0.602-a 40.7  ± 1.8
K+ 70.92  ± 0.102.97  ± 0.1613.9  ± 0.72-a

The DA concentration varied from 1 to 8 μM. The indicated Na+concentration was altered by replacing NaCl with isosmolar quantities of LiCl, choline chloride, or KCl. Shown are means ± SE ofn experiments.

  • 2-a Dunnett’s test; p < .01 versus 155 mM Na+.