Table 5

Effect of various neuroactive agents on MK-801-induced behavior

AgentCharacteristicEffect on MK-801-induced behavior
CHLORNeuroleptic- -
HALNeuroleptic- -
PERPHNeuroleptic- -
RISPNeuroleptic- -
REMNeuroleptic-
CLOZNeuroleptic- -
NECAA1 and A2 agonist-
CHAA1 agonist- -
R-PIAA1 agonist-
CGS-21680A2 agonist-
THEOA1 and A2 antagonist+
DPCPXA1 antagonist0
DMPXA2 antagonist0
d-CycloserineGlycine site agonist++
HA-966Glycine site antagonist- -
IFENPolyamine site antagonist+
NBQXAMPA/kainate antagonist0
GYKIAMPA/kainate antagonist+
CyclothiazideAMPA potentiator0
DIAZBenzodiazepine- -
Acivicinγ-GT inhibitor++
  • The following effects of the various neuroactive agents on MK-801-induced behavior are used: total inhibition (- -), reduction (-), no effect (0), minor potentiation/enhancement (+), and major potentiation (++). Abbreviations according to the list of abbreviations. A1 and A2 refer to adenosine A1 and A2 receptors. Glycine and polyamine sites refer to the NMDA receptor-associated binding sites. Note that acivicin potentiation of MK-801-induced behavior was observed in adult male rats only. All other effects were observed in adult female rats.