Table 4

Neuroleptic serum concentration in relation to the i.p. administered dose

NeurolepticDoseSerum ConcentrationCorrelation
mg/kg nM r value
CHLOR (n = 10)1.08  ± 2.6
5.087  ± 34.30.814**
10455  ± 1964-a
HAL (n = 8)0.11.0  ± 0.9
0.528  ± 2.40.937***
1.066  ± 9.4
PERPH (n = 13)0.10.8  ± 0.1
0.52.5  ± 0.60.677***
1.010  ± 2.0
RISP (n = 24)0.1<5 (10  ± 1.8)
0.518  ± 3.1 (71 ± 9.9)0.838****
2.0144  ± 32.3 (400 ± 43.0)(0.859****)
5.0324  ± 74.2 (895 ± 142)
CLOZ (n = 18)1.0<5 (15  ± 26)
5.015  ± 3.0 (11 ± 4.0)0.707**
10134  ± 40 (115 ± 42)(0.612**)
  • 4-a n = 2. The serum concentrations are presented as mean ± S.E.M. The values within parentheses represent serum concentrations ± S.E.M. for the RISP metabolite 9-OH-risperidone and the CLOZ metabolite norclozapine, respectively. *** p < .001, **** p < .0001 represent statistically significant correlation between dose and serum concentration (linear regression analysis).