Table 3

Concentrations of MK-801 in different rat brain regions

GroupPCFCHYSPSAHI
Females, 0.2 mg/kg696  ± 27.1552  ± 36.2317  ± 21.7413  ± 25.6356  ± 27.3562  ± 29.0
(100)(79)(46)(59)(51)(81)
Males, 0.2 mg/kg31  ± 2.533  ± 4.914  ± 1.719  ± 1.725  ± 4.224  ± 2.7
(100)(110) (44)(62)(80)(79)
Females, 1.0 mg/kg2455  ± 1412201  ± 2131101  ± 601634  ± 661391  ± 1302286  ± 154
(100)(90)(45)(67)(57)(93)
Males, 1.0 mg/kg108  ± 7.995  ± 8.749  ± 7.861  ± 6.650  ± 14.177  ± 6.6
(100)(88)(46)(56)(47)(72)

The concentrations of MK-801 (mean ± S.E.M.) (pmol/g) in six different brain regions around 3 to 5 h after i.p. injection. The dissection procedure was modified from Glowinski and Iversen (1966). Male rats that received either low (0.2 mg/kg) or high (1.0 mg/kg) doses of MK-801 had 20 to 25 times lower brains concentrations in all brain regions when compared with female rats that received the same i.p. dose of MK-801 (p < .0001 for all groups). The values within parentheses represent percent MK-801 concentration when compared with PC within the same group.

  • PC, parietal cortex; FC, frontal cortex; HY, hypothalamus; SP, striatum posterior; SA, striatum anterior; HI, hippocampus.