Table 3

Summary of dose recovery during rat liver perfusion

Study	Liver weight	C_In	Biliary Output		Hepatic Venous Output		Total Metabolism		Recovery
			% of input rate	% of total bile		% of input rate	% of perfusate		% of input rate	% of total metabolism		% of input rate
			% of input rate	EA-SG	EA-CG	% of input rate	EA-CYS	EA-NAC	% of input rate	EA	EA	% of input rate	EA-SG	EA-SG	EA-CG	EA-CYS	EA-NAC
	g	μM
1	9.2	8	78	88.3	11.7	0.0	0.0	0.0	35	92.0	8.0	80.2	88.7	11.3	0.0	0.0	112
2	13.6	12	75	97.0	3.0	0.0	0.0	0.0	27	93.8	6.2	76.7	97.1	2.9	0.0	0.0	102
3	12.0	15	70	92.0	8.0	0.0	0.0	0.0	35	82.1	17.9	76.1	92.7	7.3	0.0	0.0	105
4	8.4	28	44	93.0	6.7	0.0	0.3	0.0	56	79.4	20.6	55.5	94.5	5.3	0.0	0.2	100
5	9.6	49	53	94.7	5.0	0.1	0.1	0.0	60	91.5	8.5	58.4	95.2	4.6	0.1	0.1	113
6	10.2	93	30	94.9	3.0	0.4	0.6	1.1	72	94.3	5.7	33.5	96.5	2.7	0.4	0.5	102
7	11.4	112	19	99.2	0.6	0.0	0.0	0.2	81	95.9	4.1	22.4	99.5	0.5	0.0	0.0	100
8	8.6	152	14	96.5	1.7	0.6	0.5	0.7	73	97.5	2.5	15.4	97.6	1.5	0.6	0.4	87
9	11.0	153	16	98.5	1.3	0.0	0.2	0.0	84	95.9	4.1	19.1	98.7	1.1	0.0	0.2	100
10	8.2	194	14	94.1	4.7	0.8	0.1	0.3	75	96.5	3.4	16.5	95.3	4.0	0.6	0.1	89
Mean	10.2			94.8	4.6	0.2	0.2	0.2		91.9	8.1		95.6	4.1	0.2	0.2	101
S.D.	1.7			3.1	3.3	0.3	0.2	0.4		5.9	5.9		3.0	3.1	0.2	0.2	8