Brain COC and metabolites levels in neonatal rat pups
| Time | Cocaine | BE | EME | |||
|---|---|---|---|---|---|---|
| Male | Female | Male | Female | Male | Female | |
| min | ng/ml | ng/ml | ng/ml | |||
| 5 | 5413 ± 255 | 5370 ± 610 | n.d. | n.d. | n.d. | n.d. |
| 15 | 8655 ± 349 | 8686 ± 451 | 26.4 ± 2.2 | 28.1 ± 3.3 | 29.7 ± 2.7 | 35.7 ± 4.3 |
| 30 | 7362 ± 586 | 6750 ± 616 | 51.1 ± 2.0 | 53.1 ± 2.5 | 64.8 ± 4.2 | 68.3 ± 4.5 |
| 45 | 6154 ± 465 | 5996 ± 358 | 56.6 ± 6.9 | 63.1 ± 4.0 | 70.1 ± 10.6 | 79.0 ± 4.3 |
| 60 | 4917 ± 230 | 4479 ± 278 | 83.7 ± 8.1 | 100.0 ± 8.8 | 97.0 ± 6.2 | 100.2 ± 8.8 |
| 90 | 1764 ± 142 | 2050 ± 200 | 184.8 ± 0.8 | 117.8 ± 5.3 | 149.8 ± 7.0 | 150.6 ± 6.8 |
Brain levels of COC, BE, and EME in 7-day-old male and female rats after an injection of 15 mg/kg COC i.p. Results for each analyte are expressed as means ± S.E.M. in units of ng/g wet weight of brain. Brains from six same-sex animals was pooled to give one data point for each time point presented. n.d., not determined.