Table 8

Effect of systemic NTX (4 mg/kg s.c.) on extracellular Dyn B, DA, DOPAC, HVA, GABA, glutamate, and aspartate levels (mean ± S.E.) in awake animals

ParametersNeostriatum
BasalDrug% of Basal
Dyn BpM6  ± 0.911  ± 3186  ± 54
DAnM3.9  ± 0.77.6  ± 1.6182  ± 198-a
DOPACnM1058  ± 391119  ± 48106  ± 1
HVAnM1450  ± 1171540  ± 139106  ± 3
5-HIAAnM511  ± 36573  ± 60112  ± 7
GlutamatenM882  ± 1691004  ± 204123  ± 7
AspartatenM100  ± 26124  ± 34134  ± 23

The drug was administered 24 to 48 h after the implantation of the microdialysis probe, approximately 200 min after the reconnection to the perfusion system. The maximum effect observed among three successive samples taken immediately after the drug administration is expressed as the percentage of the respective basal value.N = 3–7.

  • 8-a P < .05 (Student’s pairedt test).