Indomethacin | Mediator Contents | p | Ratio | |||
---|---|---|---|---|---|---|
Before | After | TX:LTs (challenged) | After/Before | |||
mg/kg i.v. | ng/g tissue | |||||
0 | LTC4/D4/E4 | 0.82 ± 0.12 | 7.18 ± 1.23 | .0011 | 8.8 | |
TXB2 | 10.10 ± 1.08 | 71.79 ± 9.83 | .0002 | 10.0 | 7.1 | |
5 | LTC4/D4/E4 | 1.15 ± 0.40 | 33.89 ± 6.75 | .0018 | 29.5 | |
TXB2 | 3.38 ± 0.46 | 4.91 ± 0.93 | .2279 | 0.1 | 1.5 | |
1 | LTC4/D4/E4 | 0.95 ± 0.35 | 4.50 ± 0.82 | .0032 | 4.7 | |
TXB2 | 4.17 ± 0.73 | 16.37 ± 3.31 | .0066 | 3.6 | 3.9 |
Lipid mediators were measured by radioimmunoassay after the extract of lipophilic components. p values between before and after values were calculated by Student’s t test. Values are the means ± S.E. of six to nine animals.