Norepinephrine and serotonin concentration in rabbit saphenous vein: Effect of pargyline, PCPA and 6-OHDA
| Treatment | Norepinephrine | Change | Serotoninb | Change |
|---|---|---|---|---|
| nmol/g | % | nmol/g | % | |
| Vehicle (n = 5) | 5.6 ± 0.5 | 0.72 ± 0.04 | ||
| Pargyline (n = 5) | 8.6 ± 0.51-150 | +52 | 1.22 ± 0.181-150 | +69 |
| PCPA (n = 5) | 6.2 ± 1.0 | N.S. | 0.45 ± 0.051-150 | −38 |
| (30 mg/kg s.c.) | ||||
| 6-OHDA (n = 4) | 0.4 ± 0.11-150 | −93 | 0.85 ± 0.07 | N.S. |
| (100 mg/kg s.c.) |
Rabbits were treated as indicated in Materials and Methodswith the indicated inhibitors, sacrificed, and norepinephrine and serotonin content was measured in the saphenous vein. nequals number of rabbits. Values are means ± S.E.
↵1-150 P ≤ .05 as compared with control means (Dunnett’s test); N.S. indicates no significant change from control means.