Effects of ifenprodil on the cardiovascular responses to a progressive exercise test in rats
| Parameters | SAP | DAP | MAP | HR | RPP | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Groups | Placebo | Ifen | Placebo | Ifen | Placebo | Ifen | Placebo | Ifen | Placebo | Ifen | |
| mm Hg | mm Hg | mm Hg | beats/min | ||||||||
| Rest | 115 ± 4 | 120 ± 5 | 95 ± 4 | 105 ± 5 | 102 ± 4 | 111 ± 6 | 424 ± 17 | 421 ± 17 | 49 ± 3 | 50 ± 2 | |
| Level 1 (5 cm/s) | 147 ± 7 | 134 ± 6 | 129 ± 5 | 121 ± 8 | 138 ± 6 | 126 ± 8 | 521 ± 9 | 495 ± 24 | 77 ± 4 | 67 ± 6 | |
| Level 2 (15 cm/s) | 156 ± 5 | 138 ± 7 | 142 ± 5 | 122 ± 10 | 147 ± 5 | 128 ± 9 | 527 ± 10 | 501 ± 27 | 82 ± 3 | 69 ± 6 | |
| Level 3 (25 cm/s) | 166 ± 4 | 140 ± 6+ | 152 ± 4 | 122 ± 9* | 157 ± 4 | 129 ± 8* | 550 ± 7 | 506 ± 30 | 91 ± 3 | 71 ± 5* | |
| Level 4 (35 cm/s) | 172 ± 4 | 149 ± 6* | 155 ± 4 | 121 ± 12* | 160 ± 4 | 131 ± 10* | 554 ± 10 | 534 ± 24 | 96 ± 3 | 79 ± 4* | |
Placebo: rats treated with saline (n = 7); Ifen: rats treated with ifenprodil (n = 5); DAP: diastolic arterial pressure.
+P < .05; *P < .01: comparison between ifenprodil-treated animals and control animals at rest and at each level of the test (two-tailed unpaired Student’st test for comparisons).