Effect of TAK-778 on amount of soluble collagen and osteocalcin released into the culture media of rat bone marrow stromal cell
| Soluble Collagen | Osteocalcin | |
|---|---|---|
| μg/well | ng/well | |
| Control | 78.0 ± 7.6 | 3.7 ± 0.5 |
| TAK-778 | ||
| 10−8 M | 83.4 ± 6.3 | 4.5 ± 0.8 |
| 10−7 M | 114.6 ± 2.9** | 3.8 ± 0.4 |
| 10−6 M | 129.6 ± 8.9** | 9.8 ± 1.5** |
| 10−5 M | 153.0 ± 7.2** | 17.7 ± 0.7** |
| Ipriflavone, 10−5M | 115.8 ± 9.03-150 | 6.8 ± 0.8** |
Cells were cultured in medium with or without various concentrations of TAK-778 for 7 days. Mean ± S.E. (n = 5).
↵3-150 p < .05; **p < .01 versus control, Dunnett’s multiple comparison.