Potencies of antiepileptic drugs against 75 mg/kg cocaine-induced convulsions (ED50 values) and potencies of these drugs to produce behavioral toxicity on the inverted-screen test (TD50values)
| Drug | ED50 | TD50 | ED50 | TD50 |
|---|---|---|---|---|
| mg/kg | mmol/kg | |||
| Gabapentin | 11.2 (2.68–46.4) | >1700 | 0.065 | >9.930 |
| Loreclezole | 7.86 (3.07–20.1) | 60.3 (40.7–89.6) | 0.029 | 0.220 |
| Vigabatrin | 197 (90.5–427) | 1131 (797–1606) | 1.525 | 8.754 |
| Stiripentol | 68.3 (27.4–170) | 364 (186–710) | 0.292 | 1.554 |
| Progabide | 69.8 (34.1–143) | 200 (124–322) | 0.209 | 0.598 |
| Tiagabine | 4.11 (1.78–9.45) | 11.4 (7.13–18.0) | 0.011 | 0.030 |
| Losigamone | 24.7 (13.9–43.8) | 58.0 (46.8–71.9) | 0.097 | 0.228 |
| Remacemide | 38.9 (26.8–56.4) | 76.3 (63.2–92.2) | 0.145 | 0.284 |
| Felbamate | 205 (157–268) | 258 (233–285) | 0.860 | 1.083 |
| Clobazam | >17.0 | 12.2 (10.3–14.5) | >0.057 | 0.041 |
| Flunarizine | >300 | >300 | >0.742 | >0.742 |
| Lamotrigine | >56.0 | 33.0 (21.9–49.8) | >0.219 | 0.129 |
| Zonisamide | >100 | 48.6 (27.3–86.5) | >0.471 | 0.229 |
| Topiramate | >300 | 469 (263–838) | >0.884 | 1.382 |
Values are expressed in milligrams per kilogram (with 95% confidence limits in parentheses) and in millimoles per kilogram. Doses of drugs in millimoles per kilogram refer to the free-base forms. ED50and TD50 values were calculated from dose-response functions in Fig. 2.