Table 2

Effects of receptor antagonists on RB-induced increase in contraction amplitude

Antagonist2-aRB2-b AloneRB + Antagonist
Phentolamine2.16  ± 0.132.17  ± 0.15
dl-Propranolol2.20  ± 0.182.15  ± 0.13
Pyrilamine2.02  ± 0.072.09  ± 0.07
Cimetidine2.21  ± 0.182.32  ± 0.24

Papillary muscles were stimulated at 2 Hz and exposed to the agents. Contraction amplitudes represent relative values to those obtained immediately before application of the agents. Values are mean ± S.E. (n = 4).

  • 2-a Concentration of the antagonists was 5 μM.

  • 2-b Concentration of RB was 20 μM.