Effect of p.o. ZD1611 on pressor responses to big ET-1 in dogs
| ED20 (95% CLs) | n | ||
|---|---|---|---|
| 3 h | 5 h | ||
| nmol/kg | |||
| Vehicle | 0.3 (0.2–0.5) | 0.3 (0.3–0.4) | 4 |
| ZD1611 (0.6 mg/kg p.o.) | 1.3 (1.1–1.5)4-150 | 0.7 (0.4–1.2)** | 4 |
Values are the geometric mean dose of big ET-1 required to give an increase in MAP of 20 mm Hg. Dogs were treated with either vehicle or p.o. ZD1611, and comparisons were made between animals.
↵4-150 p < .001, ** p < .05 compared with vehicle control.