Table 1

Effect of troglitazone on the decrease in Isc in rat duodenum

Experimental ConditionDecrease in Isc
μA/cm2
Troglitazone (20 μM)8.56  ± 1.01
 + acetazolamide (10 mM)4.56  ± 0.221-150
 + TTX (100 nM)8.46  ± 0.88
 + amiloride (100 μM)8.02  ± 0.74
 + VIP (100 nM)21.1  ± 1.631-150
Troglitazone (20 μM)
 In HCO 3-free condition1.31  ± 0.831-150
  • 1-150 P < .01 compared with troglitazone-alone group by unpaired Student’s t test. Each value is mean ± S.E. (n = 6).