Intraluminal pressure (area under the curve in mm2) in response to electrical field stimulation before (control) and after addition of darifenacin
| 2 cm Orally | 4 cm Orally | Total Response | ||||
|---|---|---|---|---|---|---|
| mm2 | % | mm2 | % | mm2 | % | |
| Control | 162.3 ± 15.1 | 100 | 132.4 ± 23.4 | 100 | 146.6 ± 13.9 | 100 |
| Darifenacin, 0.1 nM | 161.8 ± 25.9 | 99 | 112.4 ± 25.0 | 81 | 137.1 ± 19.1 | 90 |
| Darifenacin, 1 nM | 147.1 ± 36.8 | 88 | 86.9 ± 17.9 | 60 | 117.1 ± 22.1 | 74 |
| Darifenacin, 10 nM | 110.8 ± 42.9 | 64 | 73.4 ± 14.9 | 55 | 94.8 ± 24.8 | 60 |
| Darifenacin, 100 nM | 85.8 ± 40.6 | 48 | 64.9 ± 22.0 | 46 | 76.8 ± 23.6 | 47 |
| Darifenacin, 1 μM | 41.6 ± 18.1 | 20 | 45.9 ± 27.8 | 29 | 45.2 ± 14.4 | 23 |
Data are expressed as mean ± S.E.M. of eight independent experiments at recording sites 2 and 4 cm orally to the stimulation site.