Effects of treatment with CyA alone and with SAMe on hepatic concentrations of GS and MDA in the rat
| Controls | CyA | SAMe + CyA | |
|---|---|---|---|
| Total GS, μmol · g−1liver | 3.86 ± 0.17 | 2.33 ± 0.18a | 3.22 ± 0.27a b |
| GSH, μmol · g−1 liver | 3.77 ± 0.19 | 2.22 ± 0.13a | 3.13 ± 0.19a b |
| GSH/GSSG molar ratio | 42.4 ± 4.3 | 20.5 ± 3.1a | 36.6 ± 5.4b |
| MDA, nmol · g−1liver | 20.9 ± 2.3 | 32.1 ± 3.4a | 19.3 ± 1.0b |
CyA vehicle (controls), CyA alone, or SAMe plus CyA were given for 1 week. CyA (i.p.) and SAMe (s.c.) were administered at doses of 10 mg/kg per day and 10 mg/kg every 12 h, respectively.
Data are means ± S.E. for six rats in each group.
a,b Means different from controls and CyA group, respectively (P < .05).