Effect of SIB-1508Y on variable delayed response performance in MPTP-treated monkeys
| Condition | Delay | ||||
|---|---|---|---|---|---|
| 2 s | 5 s | 10 s | 20 s | 30 s | |
| 0.5 mg/kg | |||||
| Baseline | 59.4 ± 5.3 | 61.5 ± 5.2 | 60.4 ± 5.8 | 54.8 ± 4.8 | 53.7 ± 4.5 |
| 20 min | 73.0 ± 6.01-150 | 65.0 ± 6.0 | 62.8 ± 6.3 | 52.5 ± 6.7 | 62.6 ± 5.8 |
| 24–48 h | 77.5 ± 6.51-150 | 68.3 ± 4.6 | 74.2 ± 6.2 | 67.2 ± 5.1 | 58.3 ± 3.1 |
| 1.0 mg/kg | |||||
| Baseline | 62.1 ± 4.4 | 59.4 ± 8.2 | 69.1 ± 5.2 | 64.3 ± 3.6 | 49.8 ± 7.5 |
| 20 min | 83.0 ± 4.71-150 | 75.3 ± 3.3 | 83.0 ± 4.7 | 69.0 ± 7.8 | 51.6 ± 9.0 |
| 24–48 h | 94.5 ± 3.01-150 | 91.8 ± 3.61-150 | 83.6 ± 5.9 | 82.2 ± 3.71-150 | 59.8 ± 3.5 |
| 1.5 mg/kg | |||||
| Baseline | 64.1 ± 6.8 | 65.7 ± 5.4 | 66.2 ± 5.6 | 74.1 ± 4.7 | 54.1 ± 6.0 |
| 20 min | 86.0 ± 6.41-150 | 87.7 ± 3.91-150 | 93.1 ± 2.41-150 | 73.4 ± 5.1 | 70.0 ± 5.4 |
| 24–48 h | 90.4 ± 4.31-150 | 93.5 ± 2.11-150 | 86.7 ± 4.21-150 | 75.4 ± 5.2 | 59.1 ± 9.5 |
| 2.0 mg/kg | |||||
| Baseline | 61.3 ± 5.6 | 63.2 ± 5.0 | 70.3 ± 4.2 | 55.6 ± 8.4 | 38.8 ± 10.6 |
| 20 min | 80.4 ± 7.4 | 85.4 ± 6.11-150 | 72.8 ± 7.4 | 37.6 ± 12.5 | 55.2 ± 12.8 |
| 24–48 h | 80.3 ± 8.1 | 81.3 ± 9.9 | 80.5 ± 6.1 | 76.2 ± 6.7 | 53.5 ± 7.2 |
Combined data (means ± S.E.) from all five monkeys tested. Baseline values obtained from nondrug testing sessions performed immediately before drug testing sessions.
↵1-150 p < .05 compared with the corresponding baseline assessments, post hoc paired t test, Bonferroni correction.