Table 1

Pharmacokinetic parameter estimates for CPA analogs obtained after intravenous infusion for 15 min in conscious rats

	k₁₀	k₁₂	k₂₁	V_C
	min⁻¹		ml
2′dCPA	0.18 ± 0.00	0.098 ± 0.009	0.018 ± 0.006	184 ± 19
	(31%)	(144%)	(18%)	(13%)
3′dCPA	0.39 ± 0.13	0.58 ± 0.26	0.14 ± 0.011	38 ± 12
	(21%)	(0%)	(72%)	(0%)
5′dCPA	0.39 ± 0.06	0.28 ± 0.05	0.071 ± 0.012	64 ± 9
	(10%)	(0%)	(23%)	(0%)
8MCPA	0.14 ± 0.01	0.12 ± 0.04	0.064 ± 0.009	108 ± 15
	(33%)	(12%)	(22%)	(0%)
8ECPA	0.12 ± 0.01	0.030 ± 0.008	0.039 ± 0.006	119 ± 15
	(17%)	(50%)	(19%)	(18%)
8BCPA	0.10 ± 0.07	0.045 ± 0.008	0.027 ± 0.004	129 ± 10
	(7%)	(13%)	(0%)	(1%)

Parameter estimates (mean ± S.E.; n = 6–8) ofk₁₀ (rate constant of elimination),k₁₂ (rate constant for transfer from central to peripheral compartment), k₂₁ (rate constant for transfer from peripheral to central compartment), andV_C (volume of central compartment) were obtained by fitting the time-concentration data to a two-compartment model with NONMEM as described in the text. Estimates of interindividual variability are shown as CV in parentheses.