k10 | k12 | k21 | VC | |
---|---|---|---|---|
min−1 | ml | |||
2′dCPA | 0.18 ± 0.00 | 0.098 ± 0.009 | 0.018 ± 0.006 | 184 ± 19 |
(31%) | (144%) | (18%) | (13%) | |
3′dCPA | 0.39 ± 0.13 | 0.58 ± 0.26 | 0.14 ± 0.011 | 38 ± 12 |
(21%) | (0%) | (72%) | (0%) | |
5′dCPA | 0.39 ± 0.06 | 0.28 ± 0.05 | 0.071 ± 0.012 | 64 ± 9 |
(10%) | (0%) | (23%) | (0%) | |
8MCPA | 0.14 ± 0.01 | 0.12 ± 0.04 | 0.064 ± 0.009 | 108 ± 15 |
(33%) | (12%) | (22%) | (0%) | |
8ECPA | 0.12 ± 0.01 | 0.030 ± 0.008 | 0.039 ± 0.006 | 119 ± 15 |
(17%) | (50%) | (19%) | (18%) | |
8BCPA | 0.10 ± 0.07 | 0.045 ± 0.008 | 0.027 ± 0.004 | 129 ± 10 |
(7%) | (13%) | (0%) | (1%) |
Parameter estimates (mean ± S.E.; n = 6–8) ofk10 (rate constant of elimination),k12 (rate constant for transfer from central to peripheral compartment), k21 (rate constant for transfer from peripheral to central compartment), andVC (volume of central compartment) were obtained by fitting the time-concentration data to a two-compartment model with NONMEM as described in the text. Estimates of interindividual variability are shown as CV in parentheses.