Apparent Km and Vmax values of RPR 106541 sulfoxidation by human liver microsomes
| Microsome Sample | R-Sulfoxide | S-Sulfoxide | ||
|---|---|---|---|---|
| Km | Vmax | Km | Vmax | |
| μM | nmol/min/mg | μM | nmol/min/mg | |
| RPR-HL-04 | 72.6 | 0.70 | 21.3 | 0.84 |
| RPR-HL-05 | 54.9 | 1.05 | 38.5 | 1.88 |
| RPR-HL-06 | 67.2 | 2.01 | 58.6 | 2.46 |
Incubations were conducted as described in Materials and Methods with RPR 106541 concentrations ranging from 10 to 400 μM. Kinetic parameters were determined using a one-site model.