Table 2

Urine flow rates

Treatment	Urine Collection Period
Treatment	1	2	3	4	5	6
	μl/min
1. Saline	18 ± 5	39 ± 10	86 ± 19	94 ± 28	84 ± 25	73 ± 20
2. Amantadine + saline	29 ± 11	55 ± 15	86 ± 15	82 ± 13	71 ± 16	67 ± 14
3. Kynurenic acid + saline	17 ± 4	33 ± 11	55 ± 16	70 ± 12	90 ± 24	93 ± 23
4. Amantadine + bicarbonate	31 ± 9	157 ± 27^c	165 ± 19^b	103 ± 13	70 ± 12	60 ± 10
5. Kynurenic acid + bicarbonate	21 ± 3	128 ± 12^b	144 ± 19^2-a	93 ± 13	83 ± 12	65 ± 10

Data are expressed as mean ± S.E.M. of four or five separate determinations.
↵2-a p < .05, ^b p < .01, ^c p < .001 compared with the nonbicarbonate-treated rats of the same urine collection period, ANOVA followed by Tukey’s HSD.