Experimental design for CPP experiments
| Exp. | Conditioning Phase | Test Phase 1 | Test Phase 2 |
|---|---|---|---|
| 1. NBQX induction | AMPH/saline + NBQX | Saline + vehicle | |
| 2. NBQX expression | AMPH/saline + vehicle | Saline + NBQX | |
| 3. CNQX expression | AMPH/saline + vehicle | Saline + CNQX | |
| 4. L-701,324 expression | AMPH/saline + vehicle | Saline + L-701,324 | Saline + L-701,324 |
Amphetamine (AMPH) at 0.25 mg/kg or saline administered i.p. immediately before conditioning. NBQX, CNQX, and vehicles administered i.p. 20 min before conditioning or test. L-701,324 and vehicle administered i.p. 25 min before test. For drug dose ranges, see the text.