Drug potencies in producing hypothemia in guinea pigs after oral administration
| Drug | ED50 |
|---|---|
| mg/kg p.o. | |
| F 11356 | 1.6 (0.2–12.1) |
| Sumatriptan | >40 |
| DHE | ≥40 |
| Zolmitriptan | 8.3 (0.8–68.0) |
| Naratriptan | 9.9 (1.4–47.1) |
| Rizatriptan | 12.3 (1.8–81.7) |
Values are geometric ED50 values with 95% confidence limits in parentheses.
n = 12 guinea pigs per group.