Table 1

Response rates (responses/s) and number of infusions for cocaine (mg/kg/injection) or saline for male (n = 4) and female (n = 5) monkeys

MonkeySexCocaine Treatment (mg/kg/injection)
Rate (saline)No. inf. (saline)Rate (0.01)No. inf. (0.01)Rate (0.03)No. inf. (0.03)Rate (0.1)No. inf. (0.1)Rate (0.3)No. inf. (0.3)
4393F0.06  ± 0.007.0  ± 0.00.80  ± 0.5011.0  ± 0.90.76  ± 0.3912.5  ± 0.51.63  ± 0.38130.50  ± 0.1812.0 ± 1.0
2487F0.38  ± 0.2110.0  ± 1.40.94  ± 0.639.5  ± 2.52.01  ± 0.3613 3.66  ± 0.63132.37  ± 0.2913
2490F0.05  ± 0.007.5  ± 0.50.08  ± 0.028.3  ± 0.70.12  ± 0.0310.0  ± 0.80.98  ± 0.10130.31  ± 0.0711.3 ± 0.3
2083F0.08  ± 0.047.0  ± 2.10.65  ± 0.1512.3  ± 0.32.22  ± 0.2113 2.26  ± 0.43133.69  ± 0.6913
4394F0.10  ± 0.018.5  ± 0.41.87  ± 0.5213 2.30  ± 0.2313 3.74  ± 0.29133.73  ± 0.4113
2484M0.05  ± 0.016.0  ± 0.80.10  ± 0.018.0  ± 0.52.13  ± 0.4013 2.76  ± 0.47130.96  ± 0.4012.5 ± 0.5
RN23M0.23  ± 0.0410.5  ± 0.40.83  ± 0.1112.5  ± 0.42.33  ± 0.1213 2.68  ± 0.04130.70  ± 0.1212.5 ± 0.4
1583M0.12  ± 0.009 0.38  ± 0.2110.0  ± 1.42.62  ± 0.2713 4.30  ± 0.27132.83  ± 0.1613
2087M0.03  ± 0.004.5  ± 0.40.01  ± 0.00 4 1.59  ± 0.8412.5  ± 0.42.44  ± 0.11133.15  ± 0.0413
FemaleX0.138.000.8710.821.4812.302.4513.002.1212.46
S.E.M.0.060.570.29 0.870.44 0.580.55 0.000.74 0.35
MaleX0.117.500.33 8.632.1712.883.0513.001.9112.75
S.E.M.0.051.370.18 1.800.22 0.130.42 0.000.63 0.14
nonDDX0.117.330.55 9.171.5612.672.2513.001.4512.50
(n = 3)S.E.M.0.061.740.27 2.620.45 0.170.32 0.000.85 0.29
DDcontX0.087.330.3810.102.3213.003.1113.002.4912.83
(n = 3)S.E.M.0.020.880.16 1.240.15 0.000.61 0.000.81 0.17
DDX0.188.670.9610.271.4812.002.7913.002.1412.43
(n = 3)S.E.M.0.100.730.52 1.410.68 1.000.91 0.000.99 0.57
AllX0.127.780.639.841.7912.562.7213.002.0312.59
S.E.M.0.040.640.19 0.950.28 0.330.35 0.000.47 0.20
  • nonDD, monkeys with non-dose-dependent HPA response to cocaine; DDcont, monkeys with dose-dependent HPA response to cocaine under response-contingent condition; DD, monkeys with dose-dependent HPA response to cocaine under both contingencies; No. Inf., number of infusions.