Table 2

Pharmacokinetics of quinidine with and without nadolol on low- and high-salt diets

Low-Salt DietHigh-Salt Diet
QuinidineQuinidine + nadololQuinidineQuinidine + nadolol
AUCtotal (μg · h/ml)33.8  ± 4.828.8  ± 6.02-a 26.3  ± 6.32-c 26.0  ± 5.9
AUC0–1 h (μg · h/ml)1.48  ± 0.20.72  ± 0.42-a 0.55  ± 0.42-c 0.94  ± 0.6
CL (liters/h/kg)0.23  ± 0.10.29  ± 0.1b 0.30  ± 0.22-c 0.28  ± 0.1
t½ (h)8.93  ± 1.38.31  ± 1.38.89  ± 0.67.92  ± 1.7
C max (μg/ml)2.81  ± 0.62.68  ± 0.52.28  ± 0.62-c 2.58  ± 0.6
T max (h)1.50  ± 0.81.75  ± 1.02.88  ± 1.22-c 1.79  ± 1.0

  • Data are mean ± S.D. values.

  • ↵2-a p < .05, bp < .01 quinidine + nadolol versus quinidine alone on low-salt diet.

  • ↵2-c p < .05 low- versus high-salt diet on quinidine alone.