Effects of LU111995 on idioventricular rhythm, QRS duration, and ventricular CT
| Dose | ||||
|---|---|---|---|---|
| 1 mg/kg | 3 mg/kg | 10 mg/kg | 15 mg/kg | |
| Idioventricular rhythm (beats/min) | ||||
| Control | 46 ± 4 | 46 ± 2 | 45 ± 3 | 46 ± 2 |
| LU111995 | 46 ± 4 | 44 ± 2 | 48 ± 3 | 44 ± 3 |
| QRS duration (ms) | ||||
| Control | 61 ± 4 | 61 ± 3 | 63 ± 4 | 61 ± 3 |
| LU111995 | 61 ± 3 | 62 ± 2 | 63 ± 4 | 62 ± 2 |
| ΔCT (ms) | ||||
| Control CT | 12.3 ± 4.0 | 16.5 ± 3.9 | 15.1 ± 2.9 | 16.0 ± 3.3 |
| LU111995 | −1.3 ± 0.8 | 0.6 ± 0.4 | 0.1 ± 0.5 | 0.5 ± 0.5 |
Control values were measured in 1-week intervals immediately before LU111995 administration. LU111995 values are at 2 h postdrug administration. QRS duration in control and after drug administration, conduction time in control, and its changes after drug administration ΔCT at heart pacing rate of 80 beats/min is presented. Values are mean ± S.E.M. (n = 10).