Inhibition of [3H]MK-801 binding by Zn2+(high-affinity component) in presence of 10 μM ifenprodil and by ifenprodil (high-affinity component) in presence of 100 μM Zn2+ in nine different rat brain regions
| Region | Inhibition by Zn2+ in Presence of 10 μM Ifenprodil | Inhibition by Ifenprodil in Presence of 100 μM Zn2+ | ||
|---|---|---|---|---|
| IC50 | nH | IC50 | nH | |
| μM | nM | |||
| Piriform cortex | 6.69 ± 0.73 | 1.12 ± 0.09 | 231 ± 49 | 0.94 ± 0.05 (3) |
| Amygdala | 7.47 ± 1.292-a | 1.13 ± 0.14 | 155 ± 9 | 0.92 ± 0.20 (4) |
| CA3 | 6.20 ± 0.87 | 1.34 ± 0.06 | 187 ± 56 | 0.78 ± 0.14 (3) |
| Parietal cortex | 4.72 ± 0.72b | 1.26 ± 0.08 | 160 ± 17 | 0.87 ± 0.15 (3) |
| CA1/DG | 3.84, 3.30 | 1.37, 1.34 | 157, 255 | 0.83, 0.75 (2) |
| Striatum | 5.27 ± 0.49 | 1.42 ± 0.06 | 168 ± 29 | 0.86 ± 0.10 (3) |
| Bulbus olfactorius | 4.82 ± 1.40b | 1.15 ± 0.06 | 147 ± 25 | 0.96 ± 0.17 (3) |
| Gyrus cinguli | 4.34 ± 0.69b | 1.29 ± 0.03 | 143 ± 113 | 0.94 (2) (3) |
| Superior colliculus | 3.12, 3.94 | 1.37, 1.35 | 83, 202 | 0.98, N.D. (2) |
IC50 values and Hill coefficients (nH) are given as mean ± S.D. (number of experiments in parentheses).
↵2-a Significantly higher than values designated withb (P < .05, ANOVA).
N.D., not determined (for computer analysis, nH was set equal to 1.0).