EtOH effects on macroscopic desensitization kinetics of NMDA-induced currents
| High Glycine | Low Glycine | |||||||
|---|---|---|---|---|---|---|---|---|
| 10S | 10P | 100S | 100P | 10S | 10P | 100S | 100P | |
| SS/Pk current (% change) | 18.8 ± 9* | 20.9 ± 6** | 21.2 ± 9* | 17.1 ± 24 | −9.2 ± 6 | 19.0 ± 9* | −18.9 ± 7** | −6.9 ± 11 |
| τdecay (% change) | 12.5 ± 12 | 20.9 ± 16 | 31.3 ± 17 | 39.5 ± 20 | −9.6 ± 8 | 6.4 ± 12 | −22.7 ± 7** | −9.7 ± 10 |
| N | 13 | 13 | 13 | 13 | 12 | 12 | 12 | 12 |
Values listed are the mean percentage of change ± S.E. from control SS/Pk current amplitude ratios and τdecay in the presence of low and high glycine concentrations obtained using the simultaneous EtOH coapplication protocol (S) compared with values obtained using the EtOH pretreatment protocol (P).2-a
↵2-a Comparisons between EtOH and control value with repeated measures t test: * P ≤ .05; ** P ≤ .01.