EtOH effect on NMDA-induced current under high and low glycine conditions assessed using PP or WC patch-clamp electrophysiological techniques
| 10 mM EtOH | 100 mM EtOH | |||||||
|---|---|---|---|---|---|---|---|---|
| WC | PP | WC | PP | |||||
| High | Low | High | Low | High | Low | High | Low | |
| Peak current (% change) | −8.0 ± 1* | −2.6 ± 2 | −4.1 ± 1*** | −14.0 ± 3 | −27.4 ± 2 | −25.2 ± 2 | −20.3 ± 2 | −22.8 ± 3 |
| SS current (% change) | +0.8 ± 4 | −16.0 ± 5** | +1.3 ± 3 | −12.3 ± 5* | −22.5 ± 3 | −29.1 ± 4 | −26.4 ± 4 | −38.7 ± 3* |
| N | 33 | 32 | 24 | 24 | 33 | 32 | 24 | 24 |
Values are mean percentage of change ± S.E. in amplitude of NMDA-induced peak and SS currents in the presence of 10 or 100 mM EtOH. WC data listed in this table were obtained from cells in all experiments in which the whole-cell patch-clamp method was used. Significance (∗) of individual comparisons using post hoc Multiplet test are indicated.1-a
↵1-a All individual comparisons between high and low glycine concentrations within each treatment method at either 10 or 100 mM EtOH: * P ≤ .05; ** P ≤ .01; *** P ≤ .005.