Table 3

Effects of rolipram on systemic and renal hemodynamics and urine formation (group 3)

BasalRolipram (μg/kg/min)
0.10.31
MAP (mm Hg)109  ± 6107  ± 7106  ± 7103  ± 93-150
HR (beats/min)122  ± 16126  ± 17137  ± 18** 144  ± 19**
RVR (mm Hg/ml/min/g)32  ± 527  ± 4** 25  ± 3** 23  ± 3**
FF (%)21  ± 324  ± 529  ± 721  ± 4
FENa (%)2.2  ± 0.52.8  ± 0.72.7  ± 0.62.3  ± 0.3
Uosm (Osm/kg H2O)1.1  ± 0.20.9  ± 0.10.9  ± 0.11.0  ± 0.1
Cosm (μl/min/g)16  ± 120  ± 23-150 23  ± 2** 20  ± 33-150
TCH2O (μl/min/g)11  ± 113  ± 215  ± 23-150 15  ± 2
  • Values are mean ± S.E. (n = 7). MAP, mean arterial pressure; HR, heart rate; RVR, renal vascular resistance; FF, filtration fraction; FENa, fractional Na+ excretion; Uosm, urine osmolarity; Cosm, osmolar clearance; TCH2O, free water reabsorption. Rolipram was infused into renal artery at increasing doses (0.1, 0.3, and 1 μg/kg/min).

  • 3-150P < .05, ** P < .01 compared with corresponding basal value.