Treatment | IOP before Treatment | IOP Changes at Various Time Intervals after Drug Administration | |||||
---|---|---|---|---|---|---|---|
0.5 h | 1 h | 1.5 h | 2 h | 3 h | 4 h | ||
mm Hg | |||||||
NE-100 0.1% | 10.8 ± 1.5 | 0.1 ± 0.03 | 0.18 ± 0.08 | 0.1 ± 0.03 | 0.15 ± 0.04 | 0.0 ± 0.05 | 0.14 ± 0.07 |
DTG 0.5% | 9.7 ± 2.4 | −0.003 ± 0.02 | 0.11 ± 0.02 | 0.16 ± 0.05 | 0.09 ± 0.035 | 0.18 ± 0.06 | 0.18 ± 0.07 |
(−)-Pentazocine 0.5% | 10.5 ± 1.6 | −0.06 ± 0.01 | −0.09 ± 0.070 | −0.12 ± 0.04 | 0.0 ± 0.03 | −0.09 ± 0.05 | 0.12 ± 0.038 |
Compounds were instilled (50 μl) in the left eye. Each value is mean ± S.E.M. of six or seven animals, and results are expressed as difference in millimeters of mercury (mm Hg) from pretreatment value.