Table 2

Summary of generalization testing

	Hydromorphone	Pentazocine	Butorphanol	Nalbuphine	Buprenorphine
Discrimination Operant Responding
Saline-appropriate	0.006↓	0.002↑	0.004↓	<0.001↓	0.015↓
Hydromorphone 1 mg-appropriate	0.002↑	0.002↑	0.004↑	0.006↑	0.083(↑)
Hydromorphone 4 mg-appropriate	0.006↑		0.061(↑)
Visual Analog Scales
Like saline	0.001↓	<0.001↓	0.001↓	<0.001↓	0.012↓
Like hydromorphone 1	<0.001↑	0.005↑	0.041↑	<0.001↑
Like hydromorphone 4	0.002↑	0.07(↑)	0.015↑		0.045↑
Drug effect	<0.001↑	<0.001↑	<0.001↑	0.060(↑)	0.008↑
High	<0.001↑	0.009↑	0.001↑	0.084(↑)	0.028↑
Liking	<0.001↑	0.028↑		0.037↑	0.010↑
Good effects	<0.001↑	0.007↑		0.056(↑)	0.013↑
Bad effects			0.058(↑)
Adjective Rating Scales
Agonist	0.003↑			0.065(↑)	0.024(↑)
Antagonist		0.082(↑)	0.095(↑)
Mixed
ARCI^2-a
MBG
LSD			0.062(↑)
PCAG
BG
Amphetamine
Physiological measures
Heart rate
Blood pressure
Systolic (mm Hg)					0.049↑
Diastolic (mm Hg)			0.081(↓)
Respiration rate (breaths/min)
Temperature (°F)	0.035↓
Pupil diameter (mm)	<0.001↓	0.003↓	<0.001↓	0.004↓	0.017↓
Psychomotor/Cognitive Performance
DSST no. correct			0.001↓	0.006↓
DSST no. attempted			0.002↓	0.012↓

Statistical significance of dose effects for each drug were determined by repeated-measures, one-factor ANOVA. Values represent Pvalues; all P values <.10 are shown. The directions (relative to saline) of statistically significant (P < .05) drug effects are indicated by arrows, and the direction of drug effects with P values greater than .05 and less than or equal to .10 are indicated by arrows in parentheses (n= 6).

↵2-a MBG, morphine-benzadrine group; LSD, LSD group; PCAG, pentobarbital-chloropromazine-alcohol group; BG, benzadrine group; Amphetamine, amphetamine scale.