Table 4

Hip-His-Leu hydrolysis by SHR plasma

Captopril Dose	ACE Hip-His-Leu Activity
Captopril Dose	−30 min	0 min	30 min	60 min	90 min
mg/kg	hippuric acid nmol/ml/min
0^4-a	22.4 ± 2.7	22.1 ± 2.9	20.79 ± 2.9	19.1 ± 2.4	17.7 ± 1.5
0.03^4-b	17.7 ± 3.9	16.6 ± 3.3	15.7 ± 3.3	15.0 ± 3.2	14.9 ± 3.4
0.1^4-a	18.4 ± 3.5	17.4 ± 3.4	14.0 ± 4.4	15.1 ± 2.8	15.3 ± 2.9
0.3^4-b	17.5 ± 5.4	16.7 ± 5.3	14.3 ± 4.4	15.0 ± 4.6	14.7 ± 4.7
1^4-a	16.6 ± 5.6	15.8 ± 5.1	11.7 ± 5.4^* ^4-c	13.8 ± 4.5	13.4 ± 4.4
10^4-b	16.3 ± 6.9	14.9 ± 5.5	3.4 ± 2.1^*	6.9 ± 4.0^*	8.1 ± 4.0^*

↵4-a Mean ± S.D. (n = 4).
↵4-b Mean ± S.D. (n = 12).
↵4-c Statistically significant difference from control group (p < .05).