Captopril Dose | Plasma AcSDKP Levels1-a | ||||
---|---|---|---|---|---|
−30 min | 0 min | 30 min | 60 min | 90 min | |
mg/kg | nM | ||||
0 | 1.7 ± 0.3 | 1.9 ± 0.7 | 1.8 ± 0.3 | 1.8 ± 0.4 | 1.9 ± 0.4 |
0.01 | 1.5 ± 0.2 | 1.8 ± 0.9 | 2.3 ± 0.3* 1-b | 2.3 ± 0.8* | 2.1 ± 0.5 |
0.03 | 1.8 ± 0.3 | 1.8 ± 0.4 | 4.1 ± 0.7* | 4.0 ± 0.6* | 3.8 ± 0.6* |
0.1 | 2.2 ± 1.2 | 1.9 ± 0.3 | 5.0 ± 0.8* | 5.9 ± 1.1* | 5.8 ± 0.8* |
0.3 | 1.7 ± 0.1 | 1.9 ± 0.6 | 5.6 ± 0.4* | 6.8 ± 0.9* | 7.3 ± 1.4* |
1 | 2.0 ± 0.6 | 2.1 ± 0.7 | 6.1 ± 1.3* | 8.2 ± 2.7* | 7.4 ± 2.3* |
10 | 1.7 ± 0.4 | 2.0 ± 0.5 | 5.8 ± 0.8* | 7.2 ± 1.3* | 8.4 ± 1.4* |