Drug | [125I]RTI-55 Binding HEK-hDAT Cells: Ki (nM) and Hill Slope | [3H]DA Uptake HEK-hDAT Cells: IC50 (nM) and Hill Slope | [125I]RTI-55 Binding HEK hSERT Cells:Ki (nM) and Hill Slope | [3H]5HT Uptake HEK-hSERT Cells: IC50 (nM) and Hill Slope | [125I]RTI-55 Binding HEK-hNET Cells: Ki (nM) and Hill Slope | [3H]NE Uptake HEK-hNET Cells: IC50 (nM) and Hill Slope |
---|---|---|---|---|---|---|
(+)-Amphetamine | 16,390 ± 1690 | 41 ± 11 | 92,000 ± 12,000 | 11,000 ± 3500 | 3820 ± 470 | 23.2 ± 8.2 |
1.25 ± 0.05 | 0.83 ± 0.10 | 1.09 ± 0.14 | 0.73 ± 0.19 | 1.37 ± 0.10 | 0.67 ± 0.07 | |
(−)-Amphetamine | 88,000 ± 30,000 | 138 ± 33 | 295,000 ± 68,000 | 57,000 ± 12,000 | 9630 ± 990 | 30.1 ± 7.4 |
1.09 ± 0.17 | 0.98 ± 0.34 | 1.04 ± 0.07 | 0.94 ± 0.19 | 1.86 ± 0.09 | 0.63 ± 0.09 | |
(+)-Fenfluramine | 190,000 ± 44,000 | 4100 ± 1000 | 1330 ± 660 | 43 ± 14 | 19,200 ± 4600 | 680 ± 160 |
1.31 ± 0.17 | 0.99 ± 0.19 | 1.10 ± 0.26 | 0.46 ± 0.07 | 0.90 ± 0.12 | 0.76 ± 0.12 | |
(−)-Fenfluramine | 159,000 ± 41,000 | 59,700 ± 6400 | 11,200 ± 3200 | 960 ± 240 | 26,500 ± 5100 | 8100 ± 1900 |
1.28 ± 0.12 | 1.17 ± 0.18 | 1.12 ± 0.18 | 0.78 ± 0.11 | 0.84 ± 0.10 | 0.88 ± 0.03 |
Values are the mean ± S.E.M. of three to seven experiments.