Inhibition of [3H]methylspiperone binding to D2-like dopamine receptors by pseudo-noble-gas configuration cations
| Receptor Subtype | Zinc | Cadmium | Copper | Silver | Gold | Mercury |
|---|---|---|---|---|---|---|
| D2L receptor | ||||||
| K i(μM) | 10 ± 2.0 | 2.4 ± 2.8 | 0.40 ± 0.17 | 0.32 ± 0.19 | 28 ± 18 | 0.15 ± 0.04 |
| IC50 (μM) | 133 ± 27 | 45 ± 52 | 8.0 ± 3.3 | 6.3 ± 3.8 | 553 ± 354 | 2.8 ± 0.8 |
| pseudo Hill Slope | 0.81 ± 0.11 | 0.90 ± 0.20 | 0.91 ± 0.09 | 3.3 ± 1.1 | 1.8 ± 0.04 | 1.4 ± 0.26 |
| D3 receptor | ||||||
| K i(μM) | 7.5 ± 1.4 | 2.5 ± 1.9 | 14 ± 17 | 1.3 ± 0.3 | 34 ± 16 | 0.62 ± 0.31 |
| IC50(μM) | 23 ± 6.5 | 12 ± 8.9 | 66 ± 77 | 4.7 ± 1.2 | 154 ± 73 | 2.8 ± 1.4 |
| pseudo Hill Slope | 0.84 ± 0.08 | 1.9 ± 0.91 | 1.2 ± 0.31 | 3.4 ± 1.5 | 1.1 ± 0.36 | 1.7 ± 1.0 |
| D4 receptor | ||||||
| K i (μM) | 23 ± 9.5 | 4.7 ± 2.6 | 41 ± 15 | 2.9 ± 1.3 | 61 ± 28 | 0.73 ± 0.43 |
| IC50 (μM) | 46 ± 19 | 7.9 ± 4.3 | 73 ± 26 | 4.8 ± 2.2 | 106 ± 49 | 1.8 ± 1.1 |
| pseudo Hill Slope | 1.3 ± 0.13 | 2.8 ± 1.6 | 1.1 ± 0.14 | 3.3 ± 1.1 | 1.6 ± 0.68 | 2.9 ± 0.30 |
Cation K i values were calculated from the IC50 values using the Cheng-Prussoff equation. Data are the arithmetic mean values of individual experiments (n = 3) with a S.D.