Table 2

Effects of CRA1000 H₂SO₄, CRA1001 H₂SO₄, and CP-154,526 on CRF-induced excitation of firing of LC neurons

Treatments	n	Percentage of Increase from Baseline Firing Rate
Vehicle (i.c.v.)
+ Vehicle (i.v.)	5	1.8 ± 3.9
CRF (1 μg, i.c.v.)
+ Vehicle (i.v.)	7	53.8 ± 6.9^2-a
+ CRA1000 H₂SO₄ (0.5 mg/kg, i.v.)	6	32.6 ± 8.1
+ CRA1000 H₂SO₄ (1 mg/kg, i.v.)	6	2.9 ± 6.4^2-b
+ CRA1000 H₂SO₄ (5 mg/kg, i.v.)	7	1.0 ± 9.1^2-b
+ CRA1001 H₂SO₄ (1 mg/kg, i.v.)	5	46.6 ± 5.3
+ CRA1001 H₂SO₄ (5 mg/kg, i.v.)	9	19.0 ± 10.3^2-b
Vehicle (i.c.v.)
+ Vehicle (i.v.)	5	1.8 ± 3.9
CRF (1 μg, i.c.v.)
+ Vehicle (i.v.)	5	61.9 ± 6.4^2-a
+ CP-154,526 (5 mg/kg, i.v.)	6	19.2 ± 6.6^2-b

n, Number of animals. Results are shown as mean ± S.E.
↵2-a P < .01 versus Vehicle (i.c.v.) + Vehicle (i.v.)-treated group (Dunnett’s test).
↵2-b P < .01 versus CRF (1 μg, i.c.v.) + Vehicle (i.v.)-treated group (Dunnett’s test).