Potencies (ED50 in mg/kg) of competitive NMDA antagonists to prevent convulsant effects of cocaine (75 mg/kg, i.p.) and potencies (TD50 in mg/kg) of these drugs to produce behavioral side effects on the inverted screen test
| Compound | ED50 | (95% CL) | TD50 | (95% CL) | PI (TD50/ED50) |
|---|---|---|---|---|---|
| LY 235959 | 1.38 | (0.87–2.19) | 3.19 | (1.65–6.21) | 2.31 |
| CGS 19755 | 1.53 | (.505–4.60) | 6.03 | (4.07–8.96) | 3.94 |
| NPC 17742 | 1.81 | (0.77–4.25) | 4.78 | (2.56–8.93) | 2.64 |
| LY 274614 | 3.49 | (1.65–7.35) | 5.63 | (3.17–9.99) | 1.61 |
| LY 233536 | 10.8 | (5.17–22.7) | 76.2 | (36.6–158) | 7.04 |
| CPP | 20.8 | (8.82–49.1) | 30.4 | (19.6–47.1) | 1.46 |
| NPC 12626 | 34.8 | (23.3–51.9) | 33.1 | (17.8–61.8) | 0.95 |
Values were calculated from dose-effect curves in Fig. 4. Data in parentheses are 95% CL.