Binding constants for Ang IV analogs in various bovine tissues as derived from competition curves
| AT4Ligand | Adrenal | Aorta | Heart | Hippocampus | Thymus |
|---|---|---|---|---|---|
| VYIHPF (AngIV) | 1.91 ± 0.39 × 10−9 | 1.91 ± 0.48 × 10−9 | 1.76 ± 0.44 × 10−9 | 1.58 ± 11 × 10−9 | 2.10 ± 0.36 × 10−9 |
| NleYI-6-aminohexamide | 6.77 ± 0.35 × 10−10 | 2.72 ± 0.75 × 10−9 | 3.05 ± 0.50 × 10−9 | 2.95 ± 0.17 × 10−9 | 5.30 ± 1.01 × 10−9 |
| VYPHPF (Pro3-AngIV) | 1.70 ± 0.15 × 10−9 | 5.31 ± 2.36 × 10−9 | 6.33 ± 0.01 × 10−9 | 9.92 ± 1.41 × 10−9 | 4.56 ± 0.88 × 10−9 |
| VYIGGdF | |||||
| Site 1 | 7.50 ± 0.25 × 10−10 (88%) | 1.43 ± .08 × 10−9 | 2.87 ± 0.12 × 10−9 | 5.91 ± 2.32 × 10−10 (40%) | 2.98 ± 0.43 × 10−9 |
| Site 2 | 2.40 ± 0.42 × 10−13 (12%) | 4.00 ± 1.63 × 10−13 (60%) | |||
| NleYIamide | 1.26 ± 0.03 × 10−9 | 2.40 ± 1.41 × 10−8 | 2.71 ± 0.35 × 10−8 | 4.52 ± 0.22 × 10−8 | 4.49 ± 0.16 × 10−8 |
n = 3.
Mean ± S.E.M.
See text for details.