Table 3

Comparison of hepatic clearance in control and cirrhosis

Substrates	In Vivo Oral Clearance^3-a		In Vitro Intrinsic Clearance
Substrates	Healthy subjects	Cirrhotic patients	Healthy livers	Cirrhotic livers
	ml/min		μl/min/mg
Lidocaine	1614 ± 432	700 ± 390^3-b	2.730 ± 1.550	0.400 ± 0.550^3-b
Zidovudine	2562 ± 816	686 ± 243^3-b	0.370 ± 0.140	0.170 ± 0.100^3-b
Umbelliferone	Unknown	Unknown	85.000 ± 16.000	78.000 ± 20.000
Oxazepam	136 ± 17	156 ± 31	0.020 ± 0.010	0.018 ± 0.016
	72	33
Lamotrigine	26 ± 8	24 ± 8^3-c	0.260 ± 0.150	0.210 ± 0.170
		15 ± 5^3-d
		11 ± 8^3-e

In vivo data from literature are compared with our in vitro data in liver microsomes.

↵3-a Values from literature (Colli et al., 1988; Taburet et al., 1990; Shull et al., 1976; Sonne et al., 1990; De Bony et al., 1997).
↵3-b P < .01, cirrhosis versus control.
↵3-c Moderate liver cirrhosis.
↵3-d Severe liver cirrhosis.
↵3-e Severe liver cirrhosis + ascites.