Pharmacokinetic parameters (mean ± S.E.) Cl,V ss, T 1/2, and unbound fraction (f u) of midazolam and α-OH-midazolam
| Cl | Vss | T1/2 | fu | |
|---|---|---|---|---|
| ml/min/kg | l/kg | min | % | |
| Midazolam | 74.3 ± 2.8 | 1.88 ± 0.07 | 29.0 ± 0.5 | 3.1 ± 0.1 |
| α-OH-Midazolam | 62.2 ± 2.5 | 1.18 ± 0.04 | 22.6 ± 1.2 | 4.2 ± 0.1 |
Values represent the mean of the individual Bayes estimates as derived after separate and combined administration of midazolam or α-OH-midazolam.